Presentation by Prof. Patricio Orio

Rapporteur: Patricio Orio

Invited by: Kesheng Xu

Report time: December 16, 2022, 8:00 - 9:00

Report Location: Online Conference: (Tencent Conference Number: 7668873243, Password: 639828)

Title: High-order interdependencies in the brain dynamics: from models to markers of aging

High-order correlations in the brain dynamics: from models to evolution

Report Abstract:

Brain interdependencies can be studied either from a structural/anatomical perspective ("structural connectivity", SC) or by considering statistical interdependencies ("functional connectivity", FC). Interestingly, while SC is typically pairwise (white-matter fibers start in a certain region and arrive at another), FC is not; however, most FC analyses A promising tool to study high-order interdependencies is the recently proposed O-Information, which can quantify the intrinsic statistical synergy and redundancy in groups of three or more interacting variables. In this paper we used the O-Information to investigate how high-order statistical interdependencies are affected by age. For this, we analised functional magnetic resonance imaging (fMRI) data at rest obtained from 164 healthy participants, ranging from 10 to 80 years old. Our results show that older subjects (ranging from 60 to 80 years) exhibit a higher predominance of redundant dependencies than younger subjects; moreover, this effect seems to be pervasive. Additionally, we found that these effects are highly heterogeneous across brain regions, and suggest the existence of a "redundancy core" formed by the prefrontal and motor cortices - thus involving functions such as Our methodology to assess high-order interdependencies in fMRI data has unlimited applications. code to calculate these metrics is freely available.

Rapporteur Bio:

PATRICIO ORIO, Full Professor. Department of Neuroscience, Faculty of Sciences, University of Valparaiso, Chile. He got Ph.D. in Biological Sciences. He got Ph.D. in Biological Sciences, Universidad de Chile, Santiago, Chile. Dr PATRICIO published 100 scientific papers such as Science,PNAS, got 12 Scientific Grants from Chile Fondecyt.

All students and faculty are welcome to attend!